Mtundu wa Lambda wakopa chidwi ngati chiwopsezo chatsopano pakukula kwa mliri wa COVID-19
Mtundu wa Lambda wa coronavirus, womwe udadziwika koyamba ku Peru mu Disembala, ukhoza kuchepa, komanso uli ndi mwayi woyambitsa matenda oopsa ngati sayimitsidwa. Milandu idapezeka ku Texas ndi South Carolina, ndipo mu 81% yamilandu yomwe idapezeka ku Peru.
Kusiyana kwa Lambda ali ndi kusintha komwe kumakana katemera.

Zosintha ziwiri pamtundu wa Lambda-T76I ndi L452Q-zimapangitsa kuti zikhale zopatsirana kwambiri kuposa zomwe COVID idachita padziko lonse lapansi mu 2020

Zotsatira zomaliza za kafukufukuyu zikufanana ndi zomwe gulu lina ku Chile lapeza kuti zosiyanazi zitha kupewanso ma antibodies a katemera, Chile Infection Control yanena.

Ripotili silinawunikiridwebe ndi anzawo.

Mtundu wa COVID-19 womwe umatsutsana ndi katemera umasunga akatswiri azachipatala, ogwira ntchito zaumoyo, komanso akatswiri azaumoyo patsogolo pa mliri wa COVID-19 usiku.

Kodi Lambda ndiyotani malinga ndi kafukufuku wochokera ku Chile?

Background Mzere watsopano wa SARS-CoV-2 C.37 posachedwa udasankhidwa kukhala mtundu wina wazokonda ndi WHO (Lambda variant) kutengera kuchuluka kwake kofalikira kumayiko aku South America komanso kupezeka kwa kusintha kwakanthawi mu protein ya spike. Zovuta zakusintha kwamatendawa ndikuthawa kwa chitetezo cha mthupi kuchokera ku ma antibodies osalepheretsa sizidziwikiratu.

Njira Tidapanga pseudotyped virus neutralization assay ndikudziwitsa momwe Lambda ikusinthira pakukhala ndi kachilombo komanso kuthawa mthupi pogwiritsa ntchito zitsanzo za plasma kuchokera kwa ogwira ntchito zaumoyo (HCW) ochokera m'malo awiri ku Santiago, Chile omwe adalandira chiwembu cha mankhwala awiri a CoronaVac.

Results:
Tidawona kuchulukirachulukira kotetezedwa ndi protein yolimba ya Lambda yomwe inali yayikulu kwambiri kuposa ya D614G (mzere B) kapena mitundu ya Alpha ndi Gamma. Poyerekeza ndi Mtundu wamtchire (mzere A), kusalowererapo kunachepa ndi 3.05 palimodzi pamitundu ina ya Lambda pomwe inali 2.33-khola la mtundu wa Gamma ndi 2.03 khola la Alpha.

Mawuwo Zotsatira zathu zikuwonetsa kuti kusintha komwe kumapezeka mu protein ya spike ya Lambda kusiyanasiyana kwa chidwi kumachulukitsa kufalikira ndi chitetezo cha mthupi kuthana ndi ma antibodies omwe atulutsidwa ndi CoronaVac. Izi zimalimbikitsa lingaliro loti katemera wamkulu wa katemera m'maiko omwe ali ndi ma SARS-CoV-2 ambiri akuyenera kutsatiridwa ndi kuyang'anitsitsa kwamankhwala olola kupezedwa kwatsopano komwe kumanyamula masinthidwe am'mimba ndi maphunziro a chitetezo cha mthupi pofuna kudziwa momwe kusinthaku kungakhudzire chitetezo cha mthupi komanso katemera wopambana.

Kupezeka kwa mitundu yosiyanasiyana ya nkhawa ya SARS-CoV-2 kwakhala chizindikiro cha mliri wa COVID-19 nthawi ya 2021.

Mzere watsopano wa SARS-CoV-2 C.37 posachedwa adasankhidwa kukhala zosintha zosiyanasiyana ndi WHO pa Juni 14^th ndipo adakhala ngati Lambda. Kukhalapo kwa mtundu watsopanowu kunanenedwa m'maiko opitilira 20 kuyambira pa Juni 2021 ndi magawo ambiri omwe amapezeka ochokera kumayiko aku South America, makamaka ochokera ku Chile, Peru, Ecuador ndi Argentina⁵. Chosangalatsa chatsopanochi chimadziwika ndi kupezeka kwa kuchotsedwa kwa mtundu wa ORF1a (Δ3675-3677) womwe wafotokozedwa kale mu mitundu ya Beta ndi Gamma yokhudzidwa ndikusintha Δ246-252, G75V, T76I, L452Q, F490S, T859N mu zomanga thupi⁶. Zovuta zakusintha kwamatendawa pakusocheretsa komanso kuthawira kuma antibacterial osadziwika sizidziwikiratu.

Chile pakali pano ili ndi pulogalamu yayikulu yakutemera. Malinga ndi chidziwitso cha anthu kuchokera ku Unduna wa Zaumoyo ku Chile kuyambira pa 27 Juni^th 2021, 65.6% ya anthu omwe akuwatsata (azaka 18 kapena kupitilira apo) alandila katemera wathunthu⁷. Ambiri (78.2%) a anthu omwe ali ndi katemera onse alandila katemera wa katemera wa kachilombo koyambitsa matenda a CoronaVac, omwe akuti kale amapangitsa kuti ma antibodies asatengeke koma ali otsika poyerekeza ndi plasma kapena sera yochokera kwa anthu obala.

Apa, tidagwiritsa ntchito kuyesa kwathu kofotokozera za pseudotyped virus neutralization¹² kudziwa momwe mtundu wina wa Lambda ungakhudzire mayankho omwe amatetezedwa ndi katemera wa kachilombo koyambitsa matenda a CoronaVac. Zambiri zathu zikuwonetsa kuti kusintha komwe kumapezeka mu protein ya spike ya Lambda kusiyanasiyana kumachulukitsa kutha kwadzidzidzi ndikuthawa kuthana ndi ma antibodies omwe amatengedwa ndi katemera wa kachilombo koyambitsa matenda a CoronaVac.

Njira

Ogwira ntchito zaumoyo ochokera m'malo awiri ku Santiago, Chile adapemphedwa kutenga nawo mbali. Odzipereka adalandira gawo la Mlingo iwiri ya CoronaVac, gawo lililonse limaperekedwa masiku 28 kupatula dongosolo la katemera waku Chile. Zitsanzo za plasma zidasonkhanitsidwa pakati pa Meyi ndi Juni 2021. Onse omwe atenga nawo mbali adasaina chilolezo chodziwitsidwa asanaphunzire chilichonse.

ZOMWE MUNGACHITE PA NKHANIYI:

Kusintha kwatsopano kumeneku kumadziwika ndi kupezeka kwa kuchotsedwa kosinthika mu jini ya ORF1a (Δ3675-3677) yomwe yafotokozedwa kale mumitundu yosiyanasiyana ya Beta ndi Gamma yodetsa nkhawa ndi masinthidwe Δ246-252, G75V, T76I, L452Q, F490S, T859N mu mapuloteni a 6.
Njira zomwe tidayesa kuyesa kwa ma virus a pseudotyped virus ndikuzindikira momwe mtundu wa Lambda umathandizira pakudwala komanso kuthawa kwa chitetezo chamthupi pogwiritsa ntchito zitsanzo za plasma kuchokera kwa ogwira ntchito yazaumoyo (HCW) ochokera m'malo awiri ku Santiago, Chile omwe adalandira njira ziwiri za katemera wa kachilombo ka CoronaVac. .
Izi zimalimbitsa lingaliro loti kampeni yayikulu ya katemera m'maiko omwe ali ndi kuchuluka kwa SARS-CoV-2 iyenera kutsatiridwa ndi kuwunika kozama kwa ma genomic kulola kuzindikirika kwa zodzipatula zatsopano zokhala ndi masinthidwe osinthika ndi maphunziro a chitetezo chamthupi omwe cholinga chake ndi kudziwa momwe masinthidwewa amakhudzira chitetezo chathupi komanso katemera wopambana.